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Opioid Overdose Kits: What They Are and How They Save Lives

Medically reviewed by Paul Ballas, D.O.
Written by Suzanne Mooney
Posted on June 4, 2026

Key Takeaways

  • Opioid overdose kits are emergency supply kits designed to help save lives, and knowing what they contain and how to use them can help families and communities feel more prepared.
  • View all takeaways

Opioid overdose kits can save lives. When these kits are easy to find, and more people know how to use them, it can be easier to respond quickly during an overdose emergency.

Learning what an opioid overdose kit is, who should have one, and how to use it can help families and communities prepare for an overdose emergency.

What Is an Opioid Overdose Kit?

An opioid overdose kit is a grab-and-go emergency supply kit designed to help save lives during a suspected opioid overdose. These kits give bystanders the tools and information they need to respond quickly while waiting for emergency medical help to arrive.

The most important item in an opioid overdose kit is naloxone. Naloxone is an easy-to-use, life-saving medication that can:

  • Temporarily reverse the effects of opioids
  • Restore normal breathing
  • Help keep someone alive until emergency responders arrive

Naloxone is available as a nasal spray or an injectable medication.

Because the effects of naloxone are temporary, it’s important to call 911 immediately, even if the person wakes up or starts breathing normally again.

What Goes in an Opioid Overdose Kit?

Some organizations provide preassembled opioid overdose kits, but you can also create your own. The two most important items are naloxone and instructions for how to use it. Beyond that, kits can be simple and may vary based on available supplies and local needs.

An opioid overdose kit may include:
  • Naloxone nasal spray or injectable naloxone
  • Step-by-step instructions on how to use naloxone
  • An emergency card directing people to call 911 immediately
  • A list of possible opioid overdose symptoms
  • Extra doses of naloxone
  • Disposable gloves
  • Alcohol wipes
  • Hand sanitizer
  • A CPR breathing barrier (face shield or rescue breathing mask)
  • Local emergency contact information, if recommended by your health department
  • A basic first aid kit
  • Any other supplies that may be needed

Naloxone is available at many pharmacies without a prescription. It may also be available free of charge through local health departments, harm reduction programs, and community-based organizations. A pharmacist or healthcare provider may be able to help you find free naloxone in your area.

When creating instructions and other written materials for an opioid overdose kit, consider the languages commonly spoken in your community. Providing materials in multiple languages may help more people respond quickly and confidently during an overdose emergency.

How To Maintain Your Kit

Whether you create your own naloxone kit or use a preassembled one, it's important to check the kit regularly to make sure it's up to date and ready to use in an emergency.

Here are a few tips:

  • Check the expiration date on the naloxone.
  • Replace any used, damaged, or missing items.
  • Review the instructions and other written materials to make sure they are current.
  • Remind family members, caregivers, or others where the kit is stored.

The U.S. Food and Drug Administration (FDA) requires naloxone to be labeled with an expiration date. It’s best to use naloxone that hasn’t expired. However, in an emergency, if expired naloxone is the only naloxone available, use it and call 911 right away. Expired naloxone may still be effective, and using it is better than not giving naloxone at all.

Replace expired naloxone as soon as possible. Also, store naloxone according to the package instructions. Very hot or freezing temperatures can damage medications and make them less effective.

If you have questions about storing or replacing naloxone, ask a pharmacist, healthcare provider, or local health department for guidance.

Who Should Have an Opioid Overdose Kit?

An opioid overdose kit can be helpful for anyone who may be in a position to recognize and respond to an opioid overdose. This includes people who use opioids, as well as people who spend time with someone who may be at risk of an overdose.

Because overdoses can happen unexpectedly, having a kit nearby can make it easier to act quickly in an emergency.

An opioid overdose kit may be especially useful for:

  • People who are prescribed opioid medications for pain
  • People living with opioid use disorder (OUD)
  • Family members, friends, or caregivers of someone who is at risk of opioid overdose
  • People who may be exposed to illicit opioids or other substances that could be contaminated with fentanyl
  • Substance use disorder programs
  • Schools and school staff
  • Workplaces and employees in settings where opioid exposure may be more likely

It’s best to store an opioid overdose kit somewhere easy to access in an emergency, such as:

  • At home
  • In a car, if it can be stored safely according to the manufacturer's storage and temperature guidelines
  • In a bag, backpack, or purse for people who are often on the go
  • In schools, workplaces, places of worship, and other community settings where an opioid overdose could happen

    To respond quickly to an opioid overdose, make sure the kit is easy to see and reach, and that people know where it’s stored.

    How Can I Prepare for an Opioid Emergency?

    Learning how to recognize the signs of an opioid overdose and preparing for an emergency can help you and others respond quickly and confidently.

    Signs of an Opioid Overdose

    Recognizing the signs of an opioid overdose is an important step in helping someone get the emergency medical care they need.

    Signs may include:

    • A limp body
    • Pale, clammy (damp or sweaty), or cold skin
    • Very small pupils
    • Blue, purple, or gray lips or fingernails, depending on skin tone
    • Slow, shallow, or stopped breathing
    • A slow or stopped heartbeat
    • Inability to wake up
    • Inability to speak or respond
    • Vomiting or gurgling noises

    Someone may also have signs of opioid overmedication before a full overdose occurs. Signs of opioid overmedication may include:

    • Unusual sleepiness or drowsiness
    • Low blood pressure
    • Slow or shallow breathing
    • Confusion
    • Slurred speech

      Good Samaritan Laws

      It can feel stressful or scary to try to help someone during a medical emergency. Many states have good Samaritan laws that may provide legal protection for people who call 911 and provide aid during an overdose emergency.

      These laws vary by location, so check with local officials or public health agencies to learn about the good Samaritan laws in your area.

      Training and Emergency Planning

      Plan what you would do if you thought someone was having an opioid overdose. Have conversations about your emergency plan with friends, family members, coworkers, neighbors, and anyone else who may need to respond so they feel prepared, too.

      Here are a few basics to know and share:

      • Keep track of where the opioid overdose kit is stored.
      • Call 911 right away.
      • Know your local good Samaritan laws.
      • Follow local public health guidance.
      • Discuss overdose preparedness with a healthcare provider or pharmacist.

      Naloxone is safe to give if you think someone might be having an opioid overdose. It reverses opioid effects.

      If opioids aren’t the cause, naloxone probably won’t help, but it’s still OK to give it while you call 911.

      Even if the person wakes up or seems to be improving, emergency medical care is still needed because the effects of naloxone are temporary.

      Some people may need additional doses of naloxone if their symptoms return or don’t improve after the first dose.

      If you or someone you care about is living with OUD, talk with a healthcare provider, mental health professional, or outreach program coordinator about:

      • Overdose prevention
      • Naloxone access
      • Opioid overdose risk factors

      Even if you never expect to use an opioid overdose kit, being prepared can save lives.

      Join the Conversation

      On MyOpioidRecoveryTeam, people share their experiences with opioid use disorder, get advice, and find support from others who understand.

      What’s in your opioid overdose kit? Let others know in the comments below.

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